Mfg Part Number
Ab04161-10.3
Vector Labs Ab04161-10.3 Anti-RANK-L [2A4], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing CB6 f1 mice with human RANKL protein.
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 2A4 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD254; TRANCE; RANKL; PAE30; ODF; OPGL; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor related protein that binds to, and activates, the TNF receptor related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease |
| Application Notes: | The specificity of the original format of the antibody was confirmed by ELISA analysis (IC50 = 2 nM). The original format of the antibody blocked the maturation of cells treated with sRANKL, the antibody specifically inhibits the functional activity of RANKL induction of dendritic cells maturation. The original format of the antibody promoted the inhibition of human sRANKL-stimulated bone marrow murine osteoclastogenesis in cell culture. These results showed that the original format of the antibody is a potent inhibitor of the interaction between human RANKL and its receptor RANK (US20030215450A1). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |