Mfg Part Number
Ab04163-3.3
Vector Labs Ab04163-3.3 Anti-RANK-L [WBP114_7.80], Mouse IgG2b, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing Balb/c mice with human RankL protein.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | WBP114_7.80 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD254; TRANCE; RANKL; PAE30; ODF; OPGL; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; SPR; inhibition |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2b |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor related protein that binds to, and activates, the TNF receptor related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease |
| Application Notes: | The specificity of the original format of the antibody to human RANKL was confirmed by ELISA analysis (EC50= 0.12 nM). The antibody could block the RANKL binding to RANK (IC50 = 0.22 nM). The original format of the antibody could inhibit the RANKL-inducible luciferase activity (IC50 = 1.04 nM). The binding affinity of the original format of the antibody to RANKL was measured by surface plasmon resonance (Kd= 60 pM) (WO2019080909). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |