Mfg Part Number
Ab04213-23.0
Vector Labs Ab04213-23.0 Anti-paraoxon (organophosphate) [A.17 L47K], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was generated via phage display from the Griffin.1 library by panning against reactive phosphonate ester 1.
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| Product Class: | Purified |
|---|---|
| Clone ID: | A.17 L47K |
| Synonyms: | L-Leu47Lys; A17 L47K; POX |
| Amount: | 100 μg |
| Application Codes Clone: | Catalyzation; Crystallization |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 32859757 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for paraoxon. |
| Application Notes: | This antibody is a covalent trap for Paraoxon and other organophosphate substrates, catalyzing the hydrolysis reaction through the SN2 mechanism. The catalytic parameters of this antibody were measured, and its KD was found to be 170 ± 8 μM; it exhibited a 340-fold reactivity enhancement for paraoxon relative to wild-type Ig-paraoxonase. Furthermore, its crystal structure in complex with paraoxon was determined (Mokrushina et al., 2020; PMID: 32859757). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |