Mfg Part Number
Ab04236-3.3
Vector Labs Ab04236-3.3 Anti-IL-17 [MCAF5352A (Afasevikumab)], Mouse IgG2b, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was produced by immunizing HuMab® mice with human IL-17.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | MCAF5352A (Afasevikumab) |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | IL17; IL-17A; IL17A; CTLA8; Interleukin-17A; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; IL17F; IL-17F; Interleukin-17F; IL-17F; Cytokine ML-1; IL-17AA; IL-17AF; IL-17FF |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; SPR; Block; Neutralize |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 31779513 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for human IL-17A and human IL-17F. It also binds their respective dimers — IL-17AA, IL-17AF, and IL-17FF. |
| Application Notes: | This antibody successfully completed phase I clinical trials (Mitra et al., 2014; PMID: 25398489). The pharmacokinetics of this antibody and the post-dose levels of IL-17AA and IL-17FF in healthy were assessed as part of the phase I study (Peng et al., 2018; PMID: 30547287). The crystal structure of the Fab version of this antibody was resolved, and its binding kinetics (KD) was measured at 7.78 ± 0.23 pM. Furthermore, alterations to the antibody's aromatic residues in its binding site and their effect on binding kinetics were assessed (Tilegenova et al., 2020; PMID: 31779513). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |