Mfg Part Number
Ab04238-3.3
Vector Labs Ab04238-3.3 Anti-IL-12/IL-23p40 [CNTO 1275 (Ustekinumab)], Mouse IgG2b, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was produced by immunizing human immunoglobulin transgenic mice ((CBA/J×C57/BL6/J) F2 hybrid) with human recombinant IL-12.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | CNTO 1275 (Ustekinumab) |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | p40; IL-12; IL-12p40; IL-12B; IL-23; IL-23p40 |
| Amount: | 100 μg |
| Application Codes Clone: | block; in vivo; therapeutic |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the p40 subunit of human IL-12/23. |
| Application Notes: | This antibody inhibits the interactions of IL-12 and IL-23 with the cell surface IL-12Rβ1 receptor and has been evaluated in phase I, II, and III trials as a treatment for immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn’s disease, multiple sclerosis, and ulcerative colitis (Elliott et al., 2009; PMID: 20074279) (Sands et al., 2019; PMID: 31553833). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |