Mfg Part Number
Ab04395-10.3
Vector Labs Ab04395-10.3 Anti-NA, Neuraminidase [NA-45], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was raised by taking B cells from influenza A survivors and vaccinees and immortalizing these.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | NA-45 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | EC:3.2.1.18 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; inhibition; crystallography |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the active site of neuraminidase from H9 variants of influenza A. |
| Application Notes: | The structure of the original version of this antibody was determined using cryo-EM and x-ray crystallography (Zhu et al., 2020; PMID:31757767, Gilchuk et al., 2019; PMID:31757769). This antibody was used for an ELISA on the NA protein of influenza A. The binding strength of this antibody to neuraminidase of influenza A was determined using surface plasmon resonance. This antibody was used for an egress inhibition assay on MDCK cells infected with influenza A. Here it showed its ability to inhibit egress at low concentrations. This antibody was used for a HDX-MS study. The N9 antigen showed hydrogen-deuterium exchange in the presence of this antibody (Gilchuk et al., 2019; PMID:31757769). This antibody was used for a fetuin-based ELLA NA activity assay. Here it showed inhibition of NA (Zhu et al., 2020; PMID:31757767). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |