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Mfg Part Number

Ab04433-23.0

Vector Labs Ab04433-23.0 Anti-Structural polyprotein [CHK152], Rabbit IgG, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original version of this antibody was raised by immunizing an adult C57BL/6 mice deficient for interferon regulatory factor 7 with La Reunion 2006 OPY-1 strain of CHIKV.

$570.70

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Description

Product Class: Purified
Clone ID: CHK152
Synonyms: p130
Amount: 100 μg
Application Codes Clone: ELISA; neutralization; blocking; in vivo; in vitro
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specififc for the wings of the A domain on E2 of CHIKV.
Application Notes: The structure of the original version of this antibody was determined using cryo-EM. Further the original version of this antibody was used for a neutralization assay on CHIKV and Vero cells (Sun et al., 2013; PMID:23577234) (Pal et al., 2013; PMID:23637602) (Pal et al., 2014; PMID:24829346). The original version of this antibody was used for a prophylaxis study on immunodeficient Ifnar−/− C57BL/6 mice, which were infected with CHIKV (Pal et al., 2013; PMID:23637602) (Pal et al., 2014; PMID:24829346). This antibody was used for an ELISA on diffent CHIKV virions (Pal et al., 2013; PMID:23637602). The ability of this antibody to reduce viral infection in rhesus macaques was assesed. It showed that it was indeed able to reduce the viral load in these animals (Pal et al., 2014; PMID:24829346). This antibody has shown its ability to block access to CHKV virions and to block the E2 surface glycoprotein from enzymatic cleavage by trypsin (Blijleven et al., 2022; PMID:35215863).

Product Class:	Purified
Clone ID:	CHK152
Synonyms:	p130
Amount:	100 μg
Application Codes Clone:	ELISA; neutralization; blocking; in vivo; in vitro
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specififc for the wings of the A domain on E2 of CHIKV.
Application Notes:	The structure of the original version of this antibody was determined using cryo-EM. Further the original version of this antibody was used for a neutralization assay on CHIKV and Vero cells (Sun et al., 2013; PMID:23577234) (Pal et al., 2013; PMID:23637602) (Pal et al., 2014; PMID:24829346). The original version of this antibody was used for a prophylaxis study on immunodeficient Ifnar−/− C57BL/6 mice, which were infected with CHIKV (Pal et al., 2013; PMID:23637602) (Pal et al., 2014; PMID:24829346). This antibody was used for an ELISA on diffent CHIKV virions (Pal et al., 2013; PMID:23637602). The ability of this antibody to reduce viral infection in rhesus macaques was assesed. It showed that it was indeed able to reduce the viral load in these animals (Pal et al., 2014; PMID:24829346). This antibody has shown its ability to block access to CHKV virions and to block the E2 surface glycoprotein from enzymatic cleavage by trypsin (Blijleven et al., 2022; PMID:35215863).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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