Mfg Part Number
Ab04435-23.0
Vector Labs Ab04435-23.0 Anti-env, Envelope glycoprotein gp160 [ITS090.03], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was raised by immunizing a rhesus macaque with the well-characterized neutralization-resistant SIVmac239 strain
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | ITS090.03 |
| Synonyms: | ITS90.03; gp120; Glycoprotein 120; Surface protein gp120 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; in vitro; neutralization; crystallography |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Rhesus Macaque Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognizes a highly glycosylated epitope on the gp120 core. |
| Application Notes: | The original antibody was used for a virus neutralization assay on SIV Env pseudoviruses. This antibody shows its ability to neutralize this virus (Gorman et al., 2019; PMID:31586542). This antibody was used for an competitive ELISA on SIVmac239 SOSIP.664 (Zhao et al., 2022; PMID:36068229), and on SIVmac239 gp140 FT and SIVmac239 gp120 V1V2V3-deleted gp120 core proteins. The structure of the original antibody was determined using both electron microscopy and x-ray crystallography (Gorman et al., 2019; PMID:31586542) (Zhao et al., 2022; PMID:36068229). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |