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Mfg Part Number

Ab04440-23.0

Vector Labs Ab04440-23.0 Anti-Envelope glycoprotein E2 [F5], Rabbit IgG, lambda (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was raised by panning cells from human bone marrow against VEEV TC-83.

$570.70

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Description

Product Class: Purified
Clone ID: F5
Synonyms: Structural polyprotein; Envelope glycoprotein E2; Spike glycoprotein E2
Amount: 100 μg
Application Codes Clone: ELISA; IHC; neutralization; in vivo; in vitro
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: Fab
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for amino acids 115 to 119 in the E2 A domain of VEEV.
Application Notes: The human IgG1 version of this antibody was used for an ELISA on six VEEV subtypes (Hunt et al., 2010; PMID:20644615), and on VEEV TC-83 (Hunt et al., 2011; PMID:21489591). The human IgG1 version of this antibody was used for a competitive binding assay on VEEV TC-83, to show that it can block other known neutralizing antibodies (Hunt et al., 2010; PMID:20644615). The structure of a fab fragment of this antibody was determined using cryo-EM (Porta et al., 2014; PMID:24920796). The prophylactic ability of this antibody was tested on mice, here mice were incubated with this antibody after which an attempt was made to infect them with VEEV. It showed prophylactic ability in this experiment (Hunt et al., 2011; PMID:21489591)(Schwedler et al., 2024; PMID:38170638). Further this antibody was used for immunohistochemistry on brains from treated and untreated mice (Hunt et al., 2011; PMID:21489591).

Product Class:	Purified
Clone ID:	F5
Synonyms:	Structural polyprotein; Envelope glycoprotein E2; Spike glycoprotein E2
Amount:	100 μg
Application Codes Clone:	ELISA; IHC; neutralization; in vivo; in vitro
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	Fab
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for amino acids 115 to 119 in the E2 A domain of VEEV.
Application Notes:	The human IgG1 version of this antibody was used for an ELISA on six VEEV subtypes (Hunt et al., 2010; PMID:20644615), and on VEEV TC-83 (Hunt et al., 2011; PMID:21489591). The human IgG1 version of this antibody was used for a competitive binding assay on VEEV TC-83, to show that it can block other known neutralizing antibodies (Hunt et al., 2010; PMID:20644615). The structure of a fab fragment of this antibody was determined using cryo-EM (Porta et al., 2014; PMID:24920796). The prophylactic ability of this antibody was tested on mice, here mice were incubated with this antibody after which an attempt was made to infect them with VEEV. It showed prophylactic ability in this experiment (Hunt et al., 2011; PMID:21489591)(Schwedler et al., 2024; PMID:38170638). Further this antibody was used for immunohistochemistry on brains from treated and untreated mice (Hunt et al., 2011; PMID:21489591).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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