Mfg Part Number
Ab04446-23.0
Vector Labs Ab04446-23.0 Anti-Genome polyprotein [38-3-11A], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was raised from human peripheral blood mononuclear cells. The cells were sorted and the sequence were isolated and cloned into a vector.
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 38-3-11A |
| Synonyms: | P1; Capsid protein VP0; Capsid protein VP2; Capsid protein VP3; Capsid protein VP4; VP4-VP2; P1A; P1B; P1C; Virion protein 2; Virion protein 3; Virion protein 4; Human enterovirus 71 |
| Amount: | 100 μg |
| Application Codes Clone: | FC; neutralization; IP; crystallography |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the threefold plateau epitope of the genome polyprotein of Human enterovirus 71 |
| Application Notes: | The original antibody was used for an in vitro neutralization assay against different EV71 genotypes. It showed neutralization for all genotypes tested. This antibody was used for a in vivo assay neutralization assay with EV71 in the hSCARB2-transgenic mice model. Here it showed increased survival in the subjects. This antibody was used for immunoprecipitation on the EV71 capsid. This antibody was used for flow cytometry on EV71 infected RD cells. The structure of this antibody was determined using both cryo-EM and x-ray crystallography (Huang et al., 2020; PMID:33067459). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |