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Mfg Part Number

Ab04448-10.29

Vector Labs Ab04448-10.29 Anti-VP1 protein [860-55D], Human Fab fragment, His-Tagged, lambda (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was raised from peripheral blood mononuclear cells from individuals previously infected with Human parvovirus B19.

$692.90

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Description

Product Class: Purified
Clone ID: 860-55D
Heavy Chain Modification: His-Tagged
Synonyms: HPV B19; VP1; VP2; Major capsid protein VP2; Viral protein 2; Human parvovirus B19
Amount: 100 μg
Application Codes Clone: ELISA; neutralization; IF; IP
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: Fab
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for a conformational epitope in VP2.
Application Notes: The original antibody was used for an ELISA on the VP1 protein of Human parvovirus B19. This antibody was tested for its neutralization ability in a human erythroid-cell colony-forming assay. It showed it was able to neutralize the parvovirus (Gigler et al., 1999; PMID:9971777). The structure of the original antibody was determined using cryo-EM (Sun et al., 2019; PMID:30787153). This antibody was used for immunoprecipitation on B19 capsids (Ros et al., 2006; PMID:17020940, Bönsch et al., 2010; PMID:20826697). Further this antibody was used for an immunofluorescence infectivity assay, this confirmed the neutralizing of the antibody (Ros et al., 2006; PMID:17020940). This antibody was used for immunofluorescence on B19 infected UT7/Epo cells (Bönsch et al., 2010; PMID:20826697, Quattrocchi et al., 2012; PMID:22718826).

Product Class:	Purified
Clone ID:	860-55D
Heavy Chain Modification:	His-Tagged
Synonyms:	HPV B19; VP1; VP2; Major capsid protein VP2; Viral protein 2; Human parvovirus B19
Amount:	100 μg
Application Codes Clone:	ELISA; neutralization; IF; IP
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	Fab
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for a conformational epitope in VP2.
Application Notes:	The original antibody was used for an ELISA on the VP1 protein of Human parvovirus B19. This antibody was tested for its neutralization ability in a human erythroid-cell colony-forming assay. It showed it was able to neutralize the parvovirus (Gigler et al., 1999; PMID:9971777). The structure of the original antibody was determined using cryo-EM (Sun et al., 2019; PMID:30787153). This antibody was used for immunoprecipitation on B19 capsids (Ros et al., 2006; PMID:17020940, Bönsch et al., 2010; PMID:20826697). Further this antibody was used for an immunofluorescence infectivity assay, this confirmed the neutralizing of the antibody (Ros et al., 2006; PMID:17020940). This antibody was used for immunofluorescence on B19 infected UT7/Epo cells (Bönsch et al., 2010; PMID:20826697, Quattrocchi et al., 2012; PMID:22718826).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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