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Mfg Part Number

Ab04460-1.1

Vector Labs Ab04460-1.1 Anti-Genome polyprotein [1D5], Mouse IgG1, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was raised by immunizing a mouse with Coxsackievirus A6.

$570.70

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Description

Product Class: Purified
Clone ID: 1D5
Synonyms: CA6; VP1; Capsid protein VP1
Amount: 100 μg
Application Codes Clone: ELISA; IHC; neutralization; in vivo; in vitro
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: Fab
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse Fab format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the immune-dominant antigenic site within VP1 comprising the BC, DE, EF, and HI loops of Coxsackievirus A6. It does not show the same reactivity in other Coxsackievirus variants.
Application Notes: The original antibody was used for immunohistochemistry on Coxsackievirus A6 infected mice. Further this antibody was used for an in vivo neutralization assay on BALB/c mice. The BALB/c mice were passively immunized with this antibody before being infected with Coxsackievirus A6. This significantly increased survival rates. This antibody was also used for a neutralization assay where the mouse was first infected with Coxsackievirus A6 before injecting this antibody. This also increased survival rates (Yang et al., 2016; PMID:27582066). This antibody was used for an in vitro neutralization assay, the binding of Coxsackievirus A6 to RD cells was tested and showed a decrease compared to the control. This antibody was used for an ELISA on Coxsackievirus A6 particles. The structure of this antibody was determined using Cryo-EM (Xu et al., 2017; PMID:28894095).

Product Class:	Purified
Clone ID:	1D5
Synonyms:	CA6; VP1; Capsid protein VP1
Amount:	100 μg
Application Codes Clone:	ELISA; IHC; neutralization; in vivo; in vitro
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	Fab
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse Fab format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for the immune-dominant antigenic site within VP1 comprising the BC, DE, EF, and HI loops of Coxsackievirus A6. It does not show the same reactivity in other Coxsackievirus variants.
Application Notes:	The original antibody was used for immunohistochemistry on Coxsackievirus A6 infected mice. Further this antibody was used for an in vivo neutralization assay on BALB/c mice. The BALB/c mice were passively immunized with this antibody before being infected with Coxsackievirus A6. This significantly increased survival rates. This antibody was also used for a neutralization assay where the mouse was first infected with Coxsackievirus A6 before injecting this antibody. This also increased survival rates (Yang et al., 2016; PMID:27582066). This antibody was used for an in vitro neutralization assay, the binding of Coxsackievirus A6 to RD cells was tested and showed a decrease compared to the control. This antibody was used for an ELISA on Coxsackievirus A6 particles. The structure of this antibody was determined using Cryo-EM (Xu et al., 2017; PMID:28894095).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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