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Mfg Part Number

Ab04463-23.0

Vector Labs Ab04463-23.0 Anti-Genome polyprotein [E104], Rabbit IgG, (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was raised by immunizing a C57BL/6 mouse with DENV-2.

$570.70

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Description

Product Class: Purified
Clone ID: E104
Synonyms: DV2-104; Capsid protein C; Core protein; Protein prM; Peptide pr; Small envelope protein M; Matrix protein; Envelope protein E; Dengue virus type 2
Amount: 100 μg
Application Codes Clone: FC; in vivo; in vitro; ELISA; neutralizing
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: Fab
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse Fab format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for DIII C-C′ loop of Envelope protein E of Dengue virus type 2
Application Notes: The original antibody was used for a plaque reduction assay on DENV-2 (Zhang et al., 2015; PMID:25355881, Sukupolvi-Petty et al., 2010; PMID:20592088). The Fab was incubated with DENV-2 and then added to BHK21 cells. The structure of the original antibody was determined using cryo-EM (Zhang et al., 2015; PMID:25355881). The original version of this antibody was used for flow cytometry on DENV infected cells. This antibody was used for an in vivo protection assay on BALB/c mice. Here the mice were given the antibody after infection with the DENV-2. It showed improvement over control (Sukupolvi-Petty et al., 2010; PMID:20592088). This antibody was used for an ELISA on immature virus particles. This antibody was able to promote infectivity of DENV-2. In short it made normally uninfectious immature virus infectious (da Silva Voorham et al., 2012; PMID:22431958).

Product Class:	Purified
Clone ID:	E104
Synonyms:	DV2-104; Capsid protein C; Core protein; Protein prM; Peptide pr; Small envelope protein M; Matrix protein; Envelope protein E; Dengue virus type 2
Amount:	100 μg
Application Codes Clone:	FC; in vivo; in vitro; ELISA; neutralizing
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	Fab
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse Fab format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for DIII C-C′ loop of Envelope protein E of Dengue virus type 2
Application Notes:	The original antibody was used for a plaque reduction assay on DENV-2 (Zhang et al., 2015; PMID:25355881, Sukupolvi-Petty et al., 2010; PMID:20592088). The Fab was incubated with DENV-2 and then added to BHK21 cells. The structure of the original antibody was determined using cryo-EM (Zhang et al., 2015; PMID:25355881). The original version of this antibody was used for flow cytometry on DENV infected cells. This antibody was used for an in vivo protection assay on BALB/c mice. Here the mice were given the antibody after infection with the DENV-2. It showed improvement over control (Sukupolvi-Petty et al., 2010; PMID:20592088). This antibody was used for an ELISA on immature virus particles. This antibody was able to promote infectivity of DENV-2. In short it made normally uninfectious immature virus infectious (da Silva Voorham et al., 2012; PMID:22431958).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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