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Mfg Part Number

Ab04480-23.0

Vector Labs Ab04480-23.0 Anti-Glycoprotein [523-11], Rabbit IgG, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was raised by immunizing a BALB/c mouse with several strains of rabies virus.

$570.70

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Description

Product Class: Purified
Clone ID: 523-11
Synonyms: G; RABV-G
Amount: 100 μg
Application Codes Clone: ELISA; neutralization; in vivo; blocking; crystallography
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for two discontinuous epitope regions in antigenic site III.
Application Notes: The original antibody was used for an in vivo neutralization assay. In short mice were treated with this antibody either pre infection and hamsters were treated post infection. With higher doses all mice survived and all hamster receiving the antibody within 24 hours after infection survived (Dietzschold et al., 1990; PMID:2335829, Dietzschold et al., 1992; PMID:1496020, Schumacher et al., 1989; PMID:2760222). The antibody was used for an ELISA on rabies virus glycoprotein. The structure of this antibody was determined using x-ray crystallography. Further this antibody showed the ability to block syncytia formation. The antibody was also used for an in vitro neutralization assay on rabies virus and BHK-21 cells (Yang et al., 2020; PMID:32004500), and on rabies virus and NA cells (Dietzschold et al., 1992; PMID:1496020). This antibody was used for immunofluorescence on Adrab.gp recombinant virus expressing the rabies G protein (Xiang et al., 1996; PMID:8623532).

Product Class:	Purified
Clone ID:	523-11
Synonyms:	G; RABV-G
Amount:	100 μg
Application Codes Clone:	ELISA; neutralization; in vivo; blocking; crystallography
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for two discontinuous epitope regions in antigenic site III.
Application Notes:	The original antibody was used for an in vivo neutralization assay. In short mice were treated with this antibody either pre infection and hamsters were treated post infection. With higher doses all mice survived and all hamster receiving the antibody within 24 hours after infection survived (Dietzschold et al., 1990; PMID:2335829, Dietzschold et al., 1992; PMID:1496020, Schumacher et al., 1989; PMID:2760222). The antibody was used for an ELISA on rabies virus glycoprotein. The structure of this antibody was determined using x-ray crystallography. Further this antibody showed the ability to block syncytia formation. The antibody was also used for an in vitro neutralization assay on rabies virus and BHK-21 cells (Yang et al., 2020; PMID:32004500), and on rabies virus and NA cells (Dietzschold et al., 1992; PMID:1496020). This antibody was used for immunofluorescence on Adrab.gp recombinant virus expressing the rabies G protein (Xiang et al., 1996; PMID:8623532).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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