Mfg Part Number
Ab04515-34.11-BS
Vector Labs Ab04515-34.11-BS Anti-TLR4 [107-H7], Camelid VHH, His-tagged, (1 mg)
Quick Overview
The original antibody was generated by immunizing llamas with a cocktail of murine and human Toll-like receptors (TLRs) that contained recombinant human TLR4/MD2, recombinant human TLR3, recombinant murine TLR3, and recombinant murine TLR2/Fc chimera. Peripheral blood mononuclear cells were isolated from the animals' blood for the construction of a phage display library, and the library was panned against the TLRs used for immunization.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 107-H7 |
| Heavy Chain Modification: | His-tagged |
| Synonyms: | hToll; CD284; Toll-like receptor 4 |
| Amount: | 1 mg |
| Application Codes Clone: | ELISA; Agnostic |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS only. |
| Original Format: | VHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for human TLR4. |
| Application Notes: | The binding specificity of the original version of this antibody (VHH) was tested using ELISA. In a cell-based neutralizing assay with hTLR4-overexpressing HEK cells, an agonistic effect was observed, as measured by increased NFκB expression after cell lysis compared to the control group, indicating activation or enhancement of TLR activity instead of neutralization (WO2009138494A2). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |