Mfg Part Number
Ab04527-10.0
Vector Labs Ab04527-10.0 Anti-Snake venom metalloproteinase BaP1 [MABaP1], Human IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizng BALB/c mice with 10 mg BaP1 obtained from B. asper venom emulsified in incomplete Marcol/Montanide adjuvant.
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| Product Class: | Purified |
|---|---|
| Clone ID: | MABaP1 |
| Synonyms: | BaP1; Hemorrhagic metalloproteinase BaP1; BnP1 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; neutralize |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody reacts with snake venom metalloproteinase (SVMP) BaP1 present in the venom of Bothrops asper. BaP1 is a P-I class of SVMP relevant in the local tissue damage associated with envenomations by Bothrops asper. This metalloproteinase exhibits a weak hemorrhagic activity and rapidly degrades the Aalpha-chain (FGA) of fibrinogen, and later on, degrades the Bbeta-chain (FGB) of fibrinogen. |
| Application Notes: | The antibody can bind snake venom metalloproteinases BaP1, whole venom of B. asper and BnP1 (B. neuwiedi) in an ELISA. This antibody completely neutralized in vivo hemorrhage, muscle necrosis, and inflammation induced by the toxin. This antibody completely neutralize myotoxicity induced by BaP1. In general it was capable of neutralizing biological effects of this SVMP (PMID: 20674587; 20674587). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |