Mfg Part Number
Ab04537-34.11-BS
Vector Labs Ab04537-34.11-BS Anti-Omalizumab [B6], Camelid VHH, His-tagged, (1 mg)
Quick Overview
The original antibody was generated by immunizing Lama glama with omalizumab conjugated with human serum albumin. The panning for selection of anti-omalizumab nanobodies involved a first step of pre-adsorption to remove reactive clones against epitopes other than the paratope of omalizumab. Phage supernatents were then incubated with omalizumab to isolate the original antibody.
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| Product Class: | Purified |
|---|---|
| Clone ID: | B6 |
| Heavy Chain Modification: | His-tagged |
| Synonyms: | anti-omalizumab idiotype; Xolair |
| Amount: | 1 mg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 34931798 |
| Buffer Composition: | PBS only. |
| Original Format: | VHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody shows reactivity against omalizumab, which is a humanized IgG1 monoclonal antibody which specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to the membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. It inhibits the binding of IgE to FcεRI on mast cells and basophils by binding to an antigenic epitope on IgE that overlaps with the site to which FcεRI binds. Omalizumab was designed to reduce sensitivity to allergens and is used for treating chronic idiopathic urticaria, and allergic asthma. |
| Application Notes: | The binding characterization of this antibody was done using ELISA. (PMID: 34931798). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |