Mfg Part Number
Ab04581-23.0
Vector Labs Ab04581-23.0 Anti-CD62E [CY1788], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was generated by replacing the murine variable regions of the monoclonal antibody CY1787 with human sequences.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | CY1788 |
| Synonyms: | E-selectin; ELAM-1; LECAM-2; CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; Leukocyte-endothelial cell adhesion molecule 2; CY 1788; CY-1788; humanized CY1787; hu CY1787; huCY1787; CY1788 (VHF/VLA); CY1788Vu; CY1788VB |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; inhibition; in vitro |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG4 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for E-selectin. E-selectin is a cell surface receptor that mediates the binding of neutrophils, monocytes, and some types of memory T cells to the endothelial cells that line blood vessels. |
| Application Notes: | The original version of this antibody (human IgG4) was generated, and its binding efficiency to a soluble form of E-selectin was compared to that of the parental mouse antibody via competitive ELISA. It demonstrated 65% of the binding efficiency of the parental clone. Additionally, this antibody inhibited the in vitro binding of human neutrophils to activated human umbilical vein endothelial cells (HUVECs) in vitro as effectively as the parental antibody (WO1996040942A1). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |