Mfg Part Number
Ab04589-4.3
Vector Labs Ab04589-4.3 Anti-CD22 [MB22-11], Mouse IgG2c, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was raised by immunizing a CD22-/- mice with mouse CD22.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | MB22-11 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD22; BL-CAM; B-cell receptor CD22; Siglec-2; T-cell surface antigen Leu-14; Sialic acid-binding Ig-like lectin 2; B-lymphocyte cell adhesion molecule |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; inhibition; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2c |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for mouse CD22. |
| Application Notes: | The ability of the original antibody to deplete B cell in vivo in mice was tested. It showed that is was able to deplete B cells NZB/W F1 and C57BL/6 mice. This antibody was used for an ELISA (Haas et al., 2010; PMID:20368280). The ability of this antibody to block the CD22 ligand was tested. It showed that the antibody inhibited CD22-mediated adhesion. This antibody was used in vivo on mice. Here it showed that the antibody was able to significantly reduce B cell numbers (Haas et al., 2006; PMID:16920943). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |