Mfg Part Number
Ab04590-23.0
Vector Labs Ab04590-23.0 Anti-demetalated SOD1 [D3-1], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was raised by immunizing a C57Bl/6 mouse with the antigen peptide SOD1G93A.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | D3-1 |
| Synonyms: | SOD1; SOD1G93A |
| Amount: | 100 μg |
| Application Codes Clone: | IHC; ELISA; in vivo |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 36874245 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognized SOD1A4V, SOD1H46R, SOD1G85R, SOD1G93A, and SOD1I112M, but not SOD1WT. Further the antibody did not recognize SOD1 in patients with sporadic ALS or other neurodegenerative diseases. |
| Application Notes: | The original antibody was used for immunohistochemistry on spinal cord sections from patients with FALS. This antibody was used in vivo on transgenic rats with SOD1H46R mutation. The treatment improved phenotypes and extended the lifespan of the rats. This antibody was used for an ELISA on recombinant protein SOD1G93A (Minamiyama et al., 2023; PMID:36874245). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |