Mfg Part Number
Ab04592-10.0
Vector Labs Ab04592-10.0 Anti-SOD1 [D3H5], Human IgG1, kappa (100 μg)
Quick Overview
This antibody was raised by immunizing mice with a recombinant apo form of G93A human SOD1
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | D3H5 |
| Synonyms: | SOD1; SOD1G93A; SOD1 A4V |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; WB; IHC; IP; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, chimeric human antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody was specific for misfolded SOD1 and does not bind to WT SOD1. |
| Application Notes: | The original antibody was used for an ELISA on SOD1 WT and misfolded SOD1. It only showed binding to the misfolded SOD1 protein. This antibody was used for a western blot on SOD1 WT and misfolded SOD1. This antibody was expressed in the spinal cords of mice with a SOD1 mutation simulating ALS. It showed that it delayed disease onset and extended lifespans (Patel et al., 2014; PMID:24394188). This antibody was used for immunohistochemistry on spinal cords from transgenic mice over-expressing the G93A-SOD1 mutation (Gros-Louis et al., 2010; PMID:20345765), and on SOD1G93A rat spinal cords (Pickles et al., 2016; PMID:27121871). The antibody was used for immunoprecipitation on spinal cords from transgenic mice over-expressing the G93A-SOD1 mutation. This antibody was used in vivo on G93A-SO D1 mice. It delayed the mortality on these mice (Gros-Louis et al., 2010; PMID:20345765). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |