Mfg Part Number
Ab04595-10.0
Vector Labs Ab04595-10.0 Anti-MuSK [MuSK #13], Human IgG1, kappa (100 μg)
Quick Overview
This antibody was raised by immunizing mice with human MuSK.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | MuSK #13 |
| Synonyms: | Muscle-specific kinase receptor; Muscle, skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor |
| Amount: | 100 μg |
| Application Codes Clone: | in vitro; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for human MuSK. |
| Application Notes: | The original antibody was used in vitro to test if it could activate its target. It showed to be a potent MuSK activator. The antibody was also tested in vivo on mice. Here is was shown to localize to the neuromuscular junctions here it increased innervation. This antibody did not show any delay in onset of ALS symptoms (Sengupta-Ghosh et al., 2019; PMID: 30528255). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |