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Mfg Part Number

Ab04617-10.3

Vector Labs Ab04617-10.3 Anti-SFTSV glycoprotein C [SF83], Human IgG1, Fc Silent™, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated from the peripheral blood lymphocytes of a human patient infected with SFTSV. The PBMCs were treated with SFTSV Gc extracellular segment protein to isolate the specific hybridomas.

$570.70

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Description

Product Class: Purified
Clone ID: SF83
Heavy Chain Modification: Fc Silent™
Synonyms: SFTS; SFTSV; Glycoprotein C; SFTSV Gc; Envelopment polyprotein; Severe Fever and Thrombocytopenic Syndrome Virus; arthropod-borne phleboviruses
Amount: 100 μg
Application Codes Clone: ELISA; neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody binds the severe fever and thrombocytopenic syndrome virus glycoprotein C. Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus which is transmitted to humans through the bite of an infected tick. Most patients have symptoms such as fever, low platelet count and leukopenia, and may also have symptoms such as nausea, vomiting, diarrhea, headache, muscle pain, lymphatic enlargement, and bleeding. Recently, first case of human-to-human transmission of SFTS virus was reported in Japan.
Application Notes: The binding capability of this antibody for SFTSV glycoprotein C was confirmed using ELISA and SPR. This antibody was capable of neutralizing live virus in infected Vero cells with an IC50 of 29.45±12.80mg/mL. In an in vivo animal protection experiments the INFAR -/- mice which were injected with a dose of 20 mg/kg of SF83 antibody showed a survival rate of 20%. This antibody in combination with another anti-SFTSV Gn antibody SF5 was used for the generation of a bispecific antibody. In vivo experiments with bispecific antibody increased the survival rates of animals to 100% (CN114736291; PMID:28096333).

Product Class:	Purified
Clone ID:	SF83
Heavy Chain Modification:	Fc Silent™
Synonyms:	SFTS; SFTSV; Glycoprotein C; SFTSV Gc; Envelopment polyprotein; Severe Fever and Thrombocytopenic Syndrome Virus; arthropod-borne phleboviruses
Amount:	100 μg
Application Codes Clone:	ELISA; neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody binds the severe fever and thrombocytopenic syndrome virus glycoprotein C. Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus which is transmitted to humans through the bite of an infected tick. Most patients have symptoms such as fever, low platelet count and leukopenia, and may also have symptoms such as nausea, vomiting, diarrhea, headache, muscle pain, lymphatic enlargement, and bleeding. Recently, first case of human-to-human transmission of SFTS virus was reported in Japan.
Application Notes:	The binding capability of this antibody for SFTSV glycoprotein C was confirmed using ELISA and SPR. This antibody was capable of neutralizing live virus in infected Vero cells with an IC50 of 29.45±12.80mg/mL. In an in vivo animal protection experiments the INFAR -/- mice which were injected with a dose of 20 mg/kg of SF83 antibody showed a survival rate of 20%. This antibody in combination with another anti-SFTSV Gn antibody SF5 was used for the generation of a bispecific antibody. In vivo experiments with bispecific antibody increased the survival rates of animals to 100% (CN114736291; PMID:28096333).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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