Mfg Part Number
Ab04653-34.11-BS
Vector Labs Ab04653-34.11-BS Anti-Her2/neu [HerG1M], Camelid VHH, His-tagged, (1 mg)
Quick Overview
The original antibody was selected from a humanized VH single domain antibody gene library by screening against Her2/neu antigen.
$5,162.30
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| Product Class: | Purified |
|---|---|
| Clone ID: | HerG1M |
| Heavy Chain Modification: | His-tagged |
| Synonyms: | CD340; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2 |
| Amount: | 1 mg |
| Application Codes Clone: | ELISA; inhibit; in vitro; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS only. |
| Original Format: | VHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for human Her2/neu. |
| Application Notes: | The binding specificity of this humanized single-domain antibody (sdAb; VHH) was tested in an ELISA. This antibody was used to generate an anti-Her2/neu and anti-human Ig bi-specific construct together with Ab04651 [C3]. The bi-specific construct was tested in vitro on BT474 breast cancer cells using a CCK8 assay and demonstrated a significant inhibitory effect on the growth of the breast cancer cells (approximately 50 times more effective than Herceptin). The bi-specific construct also exhibited a significantly prolonged stability in vivo in mice compared to the sdAb version of the antibody (CN110964113B). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |