Mfg Part Number
Ab04662-1.1
Vector Labs Ab04662-1.1 Anti-ST2 [C11], Mouse IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with human ST2 protein.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | C11 |
| Synonyms: | ST2; IL1RL1; IL-1RL1; DER4; T1; IL-33Rα; Interleukin-1 receptor-like 1; Protein ST2; Growth Stimulation Expressed Gene 2; suppression of tumorigenicity 2 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds soluble form of human ST2 which is a member of the interleukin (IL)-1 receptor family. IL-33 is the ligand for ST2, which is involved in reducing fibrosis and hypertrophy in mechanically strained tissues. In in vitro and in vivo models, ST2L transduces the effects of IL-33, while excess sST2 or abnormalities in ST2 signaling leads to cardiac hypertrophy, fibrosis, and ventricular dysfunction. Circulating soluble ST2 concentration is believed to reflect cardiovascular stress and fibrosis. ST2 is a new cardiovascular biomarker for assessing acute heart failure and predicting the outcome of chronic heart failure. |
| Application Notes: | The original IgG antibody binds human ST2 recombinant protein with a binding affinity of Kd= 0.5 X 10^(-10)M. This antibody was used as a capture antibody in combination with HRP labelled D12 as detection antibody for the development of a double-antibody sandwich ELISA for detection of soluble ST2 in blood samples (CN117024595). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |