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Mfg Part Number

Ab04663-10.3

Vector Labs Ab04663-10.3 Anti-ST2 [D12], Human IgG1, Fc Silent™, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with human ST2 protein.

$570.70

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Description

Product Class: Purified
Clone ID: D12
Heavy Chain Modification: Fc Silent™
Synonyms: ST2; IL1RL1; IL-1RL1; DER4; T1; IL-33Rα; Interleukin-1 receptor-like 1; Protein ST2; Growth Stimulation Expressed Gene 2; suppression of tumorigenicity 2
Amount: 100 μg
Application Codes Clone: ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds soluble form of human ST2 which is a member of the interleukin (IL)-1 receptor family. IL-33 is the ligand for ST2, which is involved in reducing fibrosis and hypertrophy in mechanically strained tissues. In in vitro and in vivo models, ST2L transduces the effects of IL-33, while excess sST2 or abnormalities in ST2 signaling leads to cardiac hypertrophy, fibrosis, and ventricular dysfunction. Circulating soluble ST2 concentration is believed to reflect cardiovascular stress and fibrosis. ST2 is a new cardiovascular biomarker for assessing acute heart failure and predicting the outcome of chronic heart failure.
Application Notes: The original IgG antibody binds human ST2 recombinant protein with a binding affinity of Kd= 0.2 X 10^(-10)M. HRP labelled version of this antibody was used as a detection antibody in combination with C11 as capture antibody for the development of a double-antibody sandwich ELISA for detection of soluble ST2 in blood samples (CN117024595).

Product Class:	Purified
Clone ID:	D12
Heavy Chain Modification:	Fc Silent™
Synonyms:	ST2; IL1RL1; IL-1RL1; DER4; T1; IL-33Rα; Interleukin-1 receptor-like 1; Protein ST2; Growth Stimulation Expressed Gene 2; suppression of tumorigenicity 2
Amount:	100 μg
Application Codes Clone:	ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds soluble form of human ST2 which is a member of the interleukin (IL)-1 receptor family. IL-33 is the ligand for ST2, which is involved in reducing fibrosis and hypertrophy in mechanically strained tissues. In in vitro and in vivo models, ST2L transduces the effects of IL-33, while excess sST2 or abnormalities in ST2 signaling leads to cardiac hypertrophy, fibrosis, and ventricular dysfunction. Circulating soluble ST2 concentration is believed to reflect cardiovascular stress and fibrosis. ST2 is a new cardiovascular biomarker for assessing acute heart failure and predicting the outcome of chronic heart failure.
Application Notes:	The original IgG antibody binds human ST2 recombinant protein with a binding affinity of Kd= 0.2 X 10^(-10)M. HRP labelled version of this antibody was used as a detection antibody in combination with C11 as capture antibody for the development of a double-antibody sandwich ELISA for detection of soluble ST2 in blood samples (CN117024595).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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