Mfg Part Number
Ab04664-10.3
Vector Labs Ab04664-10.3 Anti-sST2 [67186-6], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with recombinant human sST2 protein.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 67186-6 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | soluble ST2; ST2; IL1RL1; IL-1RL1; DER4; T1; IL-33Rα; Interleukin-1 receptor-like 1; Protein ST2; Growth Stimulation Expressed Gene 2; suppression of tumorigenicity 4 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds soluble form of human ST2 which is a member of the interleukin (IL)-1 receptor family. IL-33 is the ligand for ST2, which is involved in reducing fibrosis and hypertrophy in mechanically strained tissues. In in vitro and in vivo models, ST2L transduces the effects of IL-33, while excess sST2 or abnormalities in ST2 signaling leads to cardiac hypertrophy, fibrosis, and ventricular dysfunction. Circulating soluble ST2 concentration is believed to reflect cardiovascular stress and fibrosis. ST2 is a new cardiovascular biomarker for assessing acute heart failure and predicting the outcome of chronic heart failure. |
| Application Notes: | This antibody was used as a capture antibody in combination with HRP labelled 67186-15 as detection antibody for the development of a double-antibody sandwich ELISA for detection of soluble ST2 in blood samples (CN105259353). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |