Mfg Part Number
Ab04666-1.1
Vector Labs Ab04666-1.1 Anti-Machupo virus GP1 [MAC1], Mouse IgG1, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing mice with recombinant lymphocytic choriomeningitis virus (rLCMV)/MACV-GP and boosted with recombinant Pichinde virus (rPICV)/Junin virus (JUNV)-GP and rPICV/MACV-GP.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | MAC1 |
| Synonyms: | MACV; MACV GP1; MACV glycoprotein 1; Pre-glycoprotein polyprotein GP complex; Glycoprotein G1; Pre-GP-C; GPC; GP-C |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; neutralize |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds the TfR1 binding site in the glycoprotein GP1 of Machupo virus (MACV), which belongs to genus Mammarenavirus, family Arenaviridae. New World (NW) hemorrhagic fever (HF) arenaviruses are a group of rodent-borne zoonotic pathogens that cause severe disease with high case fatality rates upon transmission into human populations. Machupo mammarenavirus is the causative agent for Bolivian hemorrhagic fever (BHF), also known as black typhus or Ordog Fever. |
| Application Notes: | This antibody is highly specific for binding to Machupo virus and does not cross react with Junin virus. This antibody is capable of binding MACV in an ELISA. This antibody neutralized HIV-1-based virus particles, pseudotyped with full-length MACV GP and rLCMV/MACV-GP chimeric viruses in an in vitro neutralization assay with an IC50 of 0.004 μg/mL and 13.0 μg/mL respectively (PMID: 35315691). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |