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Mfg Part Number

Ab04667-21.0

Vector Labs Ab04667-21.0 Anti-Junin virus GP1 [JUN1], Mouse IgM, kappa (50 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing mice with three doses of recombinant lymphocytic choriomeningitis virus (rLCMV)/JUNV-GP and boosted with a final dose of a live attenuated vaccine, Candid#1.

$692.90

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Description

Product Class: Purified
Clone ID: JUN1
Synonyms: JUNV GP1; GPC; Glycoprotein G1; Pre-glycoprotein polyprotein GP complex; Argentinian mammarenavirus; Pre-GP-C; GD01-AG02; J200
Amount: 50 μg
Application Codes Clone: ELISA; neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds the TfR1 binding site in the GP1 subunit of the envelope glycoprotein of Junin virus (JUNV). Junin virus also known as Argentinian mammarenavirus is an arenavirus in the Mammarenavirus genus which causes Argentine Hemorrhagic Fever (AHF). Mammarenaviruses sporadically cause zoonotic infections in humans, which may lead to life-threatening viral hemorrhagic fever (VHF) disease. VHFs caused by arenaviruses are acute diseases with considerable mortality rates. Symptoms are fever, malaise, headache, nausea, diarrhea, petechial hemorrhage of the soft tissues, lethargy, and irritability. Members of the Arenaviridae family are enveloped viruses with a bi-partite RNA genome coding for four viral proteins. The virus is spread through the aerosolization of host rodent excreta.
Application Notes: This antibody is highly specific for binding to Junin virus and does not cross react with Machupo virus. This antibody is capable of binding JUNV in an ELISA. This antibody neutralized HIV-1-based virus particles, pseudotyped with full-length JUNV GP and rLCMV/JUNV-GP chimeric viruses in an in vitro neutralization assay (PMID: 35315691).

Product Class:	Purified
Clone ID:	JUN1
Synonyms:	JUNV GP1; GPC; Glycoprotein G1; Pre-glycoprotein polyprotein GP complex; Argentinian mammarenavirus; Pre-GP-C; GD01-AG02; J200
Amount:	50 μg
Application Codes Clone:	ELISA; neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds the TfR1 binding site in the GP1 subunit of the envelope glycoprotein of Junin virus (JUNV). Junin virus also known as Argentinian mammarenavirus is an arenavirus in the Mammarenavirus genus which causes Argentine Hemorrhagic Fever (AHF). Mammarenaviruses sporadically cause zoonotic infections in humans, which may lead to life-threatening viral hemorrhagic fever (VHF) disease. VHFs caused by arenaviruses are acute diseases with considerable mortality rates. Symptoms are fever, malaise, headache, nausea, diarrhea, petechial hemorrhage of the soft tissues, lethargy, and irritability. Members of the Arenaviridae family are enveloped viruses with a bi-partite RNA genome coding for four viral proteins. The virus is spread through the aerosolization of host rodent excreta.
Application Notes:	This antibody is highly specific for binding to Junin virus and does not cross react with Machupo virus. This antibody is capable of binding JUNV in an ELISA. This antibody neutralized HIV-1-based virus particles, pseudotyped with full-length JUNV GP and rLCMV/JUNV-GP chimeric viruses in an in vitro neutralization assay (PMID: 35315691).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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