Mfg Part Number
Ab04669-34.11
Vector Labs Ab04669-34.11 Anti-CD8a [VHHCD8], Camelid VHH, His-tagged, (100 μg)
Quick Overview
The original antibody was generated by immunizing a llama with CD8, followed by antibody library construction. The antibody was isolated by biopanning against CD8.
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| Product Class: | Purified |
|---|---|
| Clone ID: | VHHCD8 |
| Heavy Chain Modification: | His-tagged |
| Synonyms: | Lyt-2; Lyt2; VHH-X118; T-cell surface glycoprotein Lyt-2 ; T-cell surface glycoprotein CD8 alpha chain |
| Amount: | 100 μg |
| Application Codes Clone: | SPR; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | VHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | The antibody is specific for CD8. |
| Application Notes: | The binding affinity of the original format of the antibody to CD8 was measured by surface plasmon resonance (Kd= 0.9 nM). FACS analysis of splenocytes and lymph nodes gated on CD45+CD19−CD3+ cells, confirming that the original format of the antibody stained CD8+ cells. The antibody competed with a commercial anti-CD8α antibody, showing it bound to the CD8α chain. 89Zr-PEGylated antibody was used for PET imaging on mice, to track the presence of intratumoral CD8+ T cells (Rashidian et al., 2017; PMID: 28666979). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |