Mfg Part Number
Ab04673-23.159
Vector Labs Ab04673-23.159 Anti-HTT [iVHH4], Rabbit IgG-Fc Fusion, (100 μg)
Quick Overview
The original antibody was generated by immunizing a llama with N-terminal htt protein, followed by phage-VHH display library construction. The antibody was isolated by biopanning against wild-type or mutant N-terminal htt fragment.
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| Product Class: | Purified |
|---|---|
| Clone ID: | iVHH4 |
| Synonyms: | HTT; Huntingtin; HD protein; Huntington disease protein |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; WB; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | VHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Llama VHH format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for wild-type and mutant human huntingtin under native and denatured conditions. The antibody epitope is located between amino acids 49–148. |
| Application Notes: | The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody detected the htt by western blot analysis. The antibody could co-immunoprecipitate htt from human HD brain lysates (Schut et al., 2015; PMID: 25294428). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |