Vector Labs Ab04703-10.3 Anti-Nerve growth factor [4D4 (Fulranumab; CNTO7309)], Human IgG1, Fc Silent™, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 4D4 (Fulranumab; CNTO7309)
Heavy Chain Modification: Fc Silent™
Synonyms: NGF; NGFB; Beta-nerve growth factor; Beta-NGF; AMG-403; JNJ-42160443; CNTO-7309
Amount: 100 μg
Application Codes Clone: therapeutic; ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds nerve growth factor (NGF). NGF is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF is a neurotrophic factor that plays a key role in neuropathic and inflammatory-induced pain, promotes hyperalgesia and allodynia.
Application Notes: This antibody showed positive reactivity with human NGF in an ELISA. The original IgG antibody was reported to bind human NGF with a binding affinity of Kd= 4pM (US7601818). Upon administration, fulranumab binds to NGF, preventing its binding to and activation of the NGF receptors TrkA and p75NTR. Inhibition of the NGF pathway may prevent the perception of pain and may induce analgesia (NCI drug dictionary). A study examined the analgesic efficacy and safety of fulranumab in adults with chronic osteoarthritis pain found that fulranumab treatment resulted in statistically significant efficacy in pain measures and physical function versus placebo (PMID: 23748114). A phase I, randomized, placebo-controlled, double-blind study reported that AMG 403 was generally safe and well-tolerated in both healthy volunteers and knee osteoarthritis patients, and exhibited linear pharmacokinetics (PMID: 26449617).

Product Class:	Purified
Clone ID:	4D4 (Fulranumab; CNTO7309)
Heavy Chain Modification:	Fc Silent™
Synonyms:	NGF; NGFB; Beta-nerve growth factor; Beta-NGF; AMG-403; JNJ-42160443; CNTO-7309
Amount:	100 μg
Application Codes Clone:	therapeutic; ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted human antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds nerve growth factor (NGF). NGF is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF is a neurotrophic factor that plays a key role in neuropathic and inflammatory-induced pain, promotes hyperalgesia and allodynia.
Application Notes:	This antibody showed positive reactivity with human NGF in an ELISA. The original IgG antibody was reported to bind human NGF with a binding affinity of Kd= 4pM (US7601818). Upon administration, fulranumab binds to NGF, preventing its binding to and activation of the NGF receptors TrkA and p75NTR. Inhibition of the NGF pathway may prevent the perception of pain and may induce analgesia (NCI drug dictionary). A study examined the analgesic efficacy and safety of fulranumab in adults with chronic osteoarthritis pain found that fulranumab treatment resulted in statistically significant efficacy in pain measures and physical function versus placebo (PMID: 23748114). A phase I, randomized, placebo-controlled, double-blind study reported that AMG 403 was generally safe and well-tolerated in both healthy volunteers and knee osteoarthritis patients, and exhibited linear pharmacokinetics (PMID: 26449617).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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