Mfg Part Number
Ab04721-23.0
Vector Labs Ab04721-23.0 Anti-amyloid beta protein-bound GM1 [3G11], Rabbit IgG, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing Balb/c mice with synthesized GAβ.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 3G11 |
| Synonyms: | GAβ |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; ThT fluorescence assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgM |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for amyloid beta protein-bound GM1. |
| Application Notes: | The original antibody was generated and screened in vitro via ELISA and Thioflavin T (ThT) fluorescence measurements for its ability to bind to GAβ and inhibit Aβ polymerization. It was assessed in three polymerization systems: (1) polymerization initiated by adding Aβ fibril fragment, (2) Aβ40 polymerization initiated from GAβ40, and (3) Aβ42 polymerization initiated from GAβ42. It showed stronger inhibitory activity, particularly in Aβ40 and Aβ42 polymerization systems, and was found to influence fibril length by promoting fibril shortening or fragmentation rather than just preventing elongation (US7741448B2). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |