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Mfg Part Number

Ab04770-1.1

Vector Labs Ab04770-1.1 Anti-Osteopontin [h23C3], Mouse IgG1, kappa (100 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunizing a BALB/c mouse with human osteopontin. Then the antibody was humanized.

$570.70

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Description

Product Class: Purified
Clone ID: h23C3
Synonyms: BNSP; OPN; SPP-1; PSEC0156; Uropontin; Nephropontin; Bone sialoprotein 1; Urinary stone protein; Secreted phosphoprotein 1
Amount: 100 μg
Application Codes Clone: ELISA; WB; in vivo; in vitro
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for both human and mouse osteopontin.
Application Notes: The original antibody was used for an ELISA on human osteopontin to determine its specificity. The mouse version of this antibody was used for a western blot on both human and mouse osteopontin, here it was shown that the antibody reacts to both human and mouse osteopontin. This antibody was tested in vivo on CIA mice spleens to test the effect on lymphocytes migration, it showed that the antibody could effectively block lymphocyte migration. Furthermore the antibody could also effectively promote the apoptosis of activated lymphocytes (US20100239588A1, Fan et al., 2008; PMID:18576331). The mouse version of this antibody was used in vitro to determine its effect on ovariectomy-induced osteoporosis, in these experiments it showed that it was able to show significant inhibition in bone loss, further it showed that it was able to reduce mature OC mediated- bone resorption, finally it promotes OC apoptosis (Zhang et al., 2014; PMID:25201732).

Product Class:	Purified
Clone ID:	h23C3
Synonyms:	BNSP; OPN; SPP-1; PSEC0156; Uropontin; Nephropontin; Bone sialoprotein 1; Urinary stone protein; Secreted phosphoprotein 1
Amount:	100 μg
Application Codes Clone:	ELISA; WB; in vivo; in vitro
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for both human and mouse osteopontin.
Application Notes:	The original antibody was used for an ELISA on human osteopontin to determine its specificity. The mouse version of this antibody was used for a western blot on both human and mouse osteopontin, here it was shown that the antibody reacts to both human and mouse osteopontin. This antibody was tested in vivo on CIA mice spleens to test the effect on lymphocytes migration, it showed that the antibody could effectively block lymphocyte migration. Furthermore the antibody could also effectively promote the apoptosis of activated lymphocytes (US20100239588A1, Fan et al., 2008; PMID:18576331). The mouse version of this antibody was used in vitro to determine its effect on ovariectomy-induced osteoporosis, in these experiments it showed that it was able to show significant inhibition in bone loss, further it showed that it was able to reduce mature OC mediated- bone resorption, finally it promotes OC apoptosis (Zhang et al., 2014; PMID:25201732).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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