Mfg Part Number
Ab04771-10.3
Vector Labs Ab04771-10.3 Anti-Osteopontin [R2K1v1.7], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was created by humanizing the 2K1 mouse antibody.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | R2K1v1.7 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | BNSP; OPN; SPP-1; PSEC0156; Uropontin; Nephropontin; Bone sialoprotein 1; Urinary stone protein; Secreted phosphoprotein 1 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; in vitro; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for human osteopontin. It binds strongly to the he RGD sequence and SVVYGLR sequence of human osteopontin. |
| Application Notes: | The original antibody was used for an ELISA on human osteopontin. The effect of the antibody on blood monocyte migration was determined, it showed that the antibody was able to inhibit the migration of TNF-alpha-activated human peripheral blood monocytes. The antibody was used for a cell adhesion assay, here it showed that it was able to show a strong cell adhesion inhibitory effect. This antibody was tested in vivo on cynomolgus monkeys, it showed that it could reduce foot swelling at a dose of 50 mg/kg, lower doses showed little effect (US7807161B2). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |