Mfg Part Number
Ab04781-10.29
Vector Labs Ab04781-10.29 Anti-Autotaxin [ATXB6], Human Fab fragment, His-Tagged, kappa (100 μg)
Quick Overview
The original antibody was generated by panning a de novo human Fab-pIX library against biotinylated human ATX beta.
$692.90
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| Product Class: | Purified |
|---|---|
| Clone ID: | ATXB6 |
| Heavy Chain Modification: | His-Tagged |
| Synonyms: | ATX; Extracellular lysophospholipase D; LysoPLD; ectonucleotide pyrophosphatases/phosphodiesterases 2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; ENPP2; EC:3.1.4.39; EC:3.1.4.4 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; SPR; Neutralize |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for autotaxin, a secreted lysophospholipase D. In mammals, the enzyme produces phospholipid lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). |
| Application Notes: | The specificity of the original antibody (human Fab) was evaluated via an ELISA, with a binding affinity (KD) of 0.329 nM as measured by SPR. This antibody can be used as part of an antibody pair with Ab04780 [ATXB3] since they exhibit simultaneous binding to ATX. This antibody can neutralize ATX as assessed via FS-3 (Fluorescent Substrate) and LPC Hydrolysis assays (US20150087812A1). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |