Vector Labs Ab04812-23.0 Anti-CD39 [mAb2], Rabbit IgG, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: mAb2
Synonyms: ENTPD1; NTPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen
Amount: 100 μg
Application Codes Clone: ELISA; FC; Inhibition
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for human CD39, also known as NTPDase 1 (ectonucleoside triphosphate diphosphohydrolase) or vascular CD39. CD39 works in concert with CD73 (ecto-5'-nucleotidase) to hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP), generating adenosine. The resulting adenosine binds to adenosine receptors, inhibiting T-cell and natural killer (NK)-cell responses, thus suppressing immune system activity. Additionally, CD39 may play a role in preventing platelet aggregation by converting platelet-activating ADP into AMP.
Application Notes: The specificity of the original version of this antibody (Human IgG1, Fc Silent) was assessed using ELISA. Among the tested targets — vascular CD39 and the CD39 isoforms L1, L2, L3, and L4 — the antibody exclusively bound to vascular CD39. In a flow cytometry (FC) assay using Ramos human lymphoma cells, which express CD39, the antibody demonstrated strong binding. Additionally, the antibody exhibited potent inhibition of CD39 activity, as measured by a MALDI-TOF (Mass Spectrometry) assay, effectively blocking over 90% of CD39's enzymatic activity (US20220056145A1).

Product Class:	Purified
Clone ID:	mAb2
Synonyms:	ENTPD1; NTPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen
Amount:	100 μg
Application Codes Clone:	ELISA; FC; Inhibition
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for human CD39, also known as NTPDase 1 (ectonucleoside triphosphate diphosphohydrolase) or vascular CD39. CD39 works in concert with CD73 (ecto-5'-nucleotidase) to hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP), generating adenosine. The resulting adenosine binds to adenosine receptors, inhibiting T-cell and natural killer (NK)-cell responses, thus suppressing immune system activity. Additionally, CD39 may play a role in preventing platelet aggregation by converting platelet-activating ADP into AMP.
Application Notes:	The specificity of the original version of this antibody (Human IgG1, Fc Silent) was assessed using ELISA. Among the tested targets — vascular CD39 and the CD39 isoforms L1, L2, L3, and L4 — the antibody exclusively bound to vascular CD39. In a flow cytometry (FC) assay using Ramos human lymphoma cells, which express CD39, the antibody demonstrated strong binding. Additionally, the antibody exhibited potent inhibition of CD39 activity, as measured by a MALDI-TOF (Mass Spectrometry) assay, effectively blocking over 90% of CD39's enzymatic activity (US20220056145A1).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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