Mfg Part Number
Ab04832-10.3
Vector Labs Ab04832-10.3 Anti-IL-1B [1F3], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing New Zealand white rabbits with recombinant human IL-1B protein.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 1F3 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | IL1B; IL-1β; 1L1F2; Interleukin-1 beta; IL-1 beta; interleukin-1β; Catabolin |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Rabbit IgG format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human Interleukin-1 beta, which is a potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. It promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. It also plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. |
| Application Notes: | This antibody can be used for detection of IL-1B using ELISA. A combination of 10A10 and 1F3 was used for the detection of IL-1B in a double antibody sandwich assay, where 10A10 was used as a capture antibody and 1F3 was used as detection antibody (CN115772220). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |