Mfg Part Number
Ab04902-10.3
Vector Labs Ab04902-10.3 Anti-CD28 [TGN1412 (Theralizumab)], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original mouse antibody 5.11A1 was generated by immunizing BALB/c mice with recombinant human CD28-Fc fusion protein and boosted with B lymphoma cell line transfected with human CD28. Later on the CDRs of the original mouse antibody were cloned into human IgG1 framework regions to obtain the humanized antibody.
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| Product Class: | Purified |
|---|---|
| Clone ID: | TGN1412 (Theralizumab) |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | T-cell-specific surface glycoprotein CD28; TP44; TGN1112; 5.11A1; CD28-SuperMAB; TAB08; 9D7 |
| Amount: | 100 μg |
| Application Codes Clone: | therapeutic |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG4 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a reformatted human IgG1 Fc Silent Fc Silent™ antibody, based on the original human IgG4 format, created for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for human CD28. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins. |
| Application Notes: | This antibody is the humanized version of the mouse anti-human CD28 5.11A1 antibody. Theralizumab (TGN1412) is a superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. This antibody can be used for detection of CD28 expressed on surface of cells using flow cytometry. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |