Mfg Part Number
Ab04903-3.3
Vector Labs Ab04903-3.3 Anti-CD221 [h7C10 (Dalotuzumab)], Mouse IgG2b, Fc Silent™, kappa (100 μg)
Quick Overview
Vector Labs Ab04903-3.3 Anti-CD221 [h7C10 (Dalotuzumab)], Mouse IgG2b, Fc Silent™, kappa (100 μg)
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | h7C10 (Dalotuzumab) |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | IGF1R; IGF-1R; IGF-IR; IGF-I receptor; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; MK-0646, humanized 7C10 |
| Amount: | 100 μg |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse format, created for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human CD221. |
| Application Notes: | Dalotuzumab binds to membrane-bound IGF1R, preventing binding of the ligand IGF1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. The activation of IGF1R, a tyrosine kinase and a member of the insulin receptor family, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF1R signaling has been highly implicated in tumorigenesis and metastasis. (National Cancer Institute, NCI Drug Dictionary). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |