Mfg Part Number
Ab04905-10.3
Vector Labs Ab04905-10.3 Anti-CTGF [FG-3019 (Pamrevlumab)], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
Vector Labs Ab04905-10.3 Anti-CTGF [FG-3019 (Pamrevlumab)], Human IgG1, Fc Silent™, kappa (100 μg)
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | FG-3019 (Pamrevlumab) |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | IGFBP8; IGFBP-8; IBP-8; CCN2; HCS24; IGF-binding protein 8; Connective Tissue Growth factor; CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8 |
| Amount: | 100 μg |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a reformatted human IgG1 Fc Silent Fc Silent™ antibody, based on the original human format, created for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human CTGF. |
| Application Notes: | Pamrevlumab binds to CTGF thereby preventing the binding of the ligand to the receptor and subsequent receptor activation. As CTGF enhances the production of collagen and fibronectin, FG-319 may prevent and reverse fibrosis. In addition, FG-3019 may prevent tumor cell proliferation in CTGF-expressing tumor cells. CTGF, a member of the CCN family (CTGF, CYR61/CEF and NOV), is expressed in a variety of tumor cell types and is involved in processes such as cell proliferation, cell migration, cell adhesion, differentiation and angiogenesis. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |