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Mfg Part Number

Ab05015-10.3

Vector Labs Ab05015-10.3 Anti-CXCL10 [1C5 ], Human IgG1, Fc Silent™, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunzing New Zealand white rabbits with recombinantly expressed extracellular region of human CXCL10 (IP-10).

$570.70

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Description

Product Class: Purified
Clone ID: 1C5
Heavy Chain Modification: Fc Silent™
Synonyms: IP-10; INP10; SCYB10; Gamma-IP10; C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Small-inducible cytokine B10; interferon-inducible protein 10
Amount: 100 μg
Application Codes Clone: ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent Fc Silent™ antibody, based on the original human IgG format, created for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds human CXCL10. This pro-inflammatory cytokine is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatin effects. This protein plays an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization.
Application Notes: This antibody can be used for the detection of human CXCL10 in an ELISA. A combination of 10D5 and 1C5 can be used in a double antibody sandwich ELISA, where 10D5 is used as a capture antibody and 1C5 is used as a detection antibody. The sensitivity of human CXCL10 detection for this pair was reported to be 1.2ng/ml (CN114656561).

Product Class:	Purified
Clone ID:	1C5
Heavy Chain Modification:	Fc Silent™
Synonyms:	IP-10; INP10; SCYB10; Gamma-IP10; C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Small-inducible cytokine B10; interferon-inducible protein 10
Amount:	100 μg
Application Codes Clone:	ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This is a reformatted human IgG1 Fc Silent Fc Silent™ antibody, based on the original human IgG format, created for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds human CXCL10. This pro-inflammatory cytokine is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatin effects. This protein plays an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization.
Application Notes:	This antibody can be used for the detection of human CXCL10 in an ELISA. A combination of 10D5 and 1C5 can be used in a double antibody sandwich ELISA, where 10D5 is used as a capture antibody and 1C5 is used as a detection antibody. The sensitivity of human CXCL10 detection for this pair was reported to be 1.2ng/ml (CN114656561).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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