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Mfg Part Number

Ab05046-10.3

Vector Labs Ab05046-10.3 Anti-NMDAR1 [6A7], Human IgG1, Fc Silent™, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with a recombinant human NMDAR1-6his protein (corresponding to amino acids 201-549 of the extracellular region of human NMDAR1).

$570.70

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Description

Product Class: Purified
Clone ID: 6A7
Heavy Chain Modification: Fc Silent™
Synonyms: GRIN1; GluN1; NMDAR1; NMD-R1; hNR1; NMDAR; N-methyl-D-aspartate receptor; NMDA receptor; Glutamate receptor ionotropic, NMDA 1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1
Amount: 100 μg
Application Codes Clone: ELISA; IF
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody specifically recognizes human NMDAR1, an ion channel protein located on the postsynaptic membrane of nerve cells. NMDAR1 is a key subunit of N-methyl-D-aspartate (NMDA) receptors, which are heterotetrameric, ligand-gated cation channels characterized by high calcium permeability and voltage-dependent Mg²⁺ block. NMDA receptors play a central role in synaptic plasticity, contributing to long-term potentiation (LTP) underlying learning and memory. The NMDAR1 subunit (GluN1) is also the primary target of autoantibodies in anti-NMDAR encephalitis, making it an important diagnostic biomarker.
Application Notes: This antibody was reported to be used for the detection of recombinant human NMDAR1 using ELISA. This antibody was also used for the indirect immunofluorescence staining of serum and cerebrospinal fluid samples of NMDAR1-positive patients (CN118878687).

Product Class:	Purified
Clone ID:	6A7
Heavy Chain Modification:	Fc Silent™
Synonyms:	GRIN1; GluN1; NMDAR1; NMD-R1; hNR1; NMDAR; N-methyl-D-aspartate receptor; NMDA receptor; Glutamate receptor ionotropic, NMDA 1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1
Amount:	100 μg
Application Codes Clone:	ELISA; IF
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This is a reformatted human IgG1 Fc Silent Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody specifically recognizes human NMDAR1, an ion channel protein located on the postsynaptic membrane of nerve cells. NMDAR1 is a key subunit of N-methyl-D-aspartate (NMDA) receptors, which are heterotetrameric, ligand-gated cation channels characterized by high calcium permeability and voltage-dependent Mg²⁺ block. NMDA receptors play a central role in synaptic plasticity, contributing to long-term potentiation (LTP) underlying learning and memory. The NMDAR1 subunit (GluN1) is also the primary target of autoantibodies in anti-NMDAR encephalitis, making it an important diagnostic biomarker.
Application Notes:	This antibody was reported to be used for the detection of recombinant human NMDAR1 using ELISA. This antibody was also used for the indirect immunofluorescence staining of serum and cerebrospinal fluid samples of NMDAR1-positive patients (CN118878687).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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