Mfg Part Number
Ab05056-10.0
Vector Labs Ab05056-10.0 Anti-CD70 [2H7], Human IgG1, kappa (100 μg)
Quick Overview
This antibody was raised by immunizing HuMab mice with recombinant human CD70.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 2H7 |
| Synonyms: | CD27-L; CD27LG; TNFSF7; CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7 |
| Amount: | 100 μg |
| Application Codes Clone: | in vitro; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for human CD70. |
| Application Notes: | This antibody was used to create a antibody drug conjugate with glucocorticoid payloads, it was used for a cellular assay using CD70-positive 786-O cells, it was shown that the antibody drug conjugate can increase GILZ mRNA expression in these cells (Kern et al., 2016; PMID:27469406, Kern et al., 2016; PMID:26745435). The uncialamycin ADC version of this antibody was tested for its ability to inhibit proliferation of 786-O cells, it showed that it was able to with IC50 partially dependent on the linker used (Chowdari et al., 2019; PMID:30579797). The original antibody was used for flow cytometry on human CD4 positive cells to determine receptor density (Mazor et al., 2015; PMID:25730144). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |