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Mfg Part Number

Ab05078-1.1

Vector Labs Ab05078-1.1 Anti-CD2 [OKT11], Mouse IgG1, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing mice with human acute lymphoblastic leukemia cells.

$570.70

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Description

Product Class: Purified
Clone ID: OKT11
Synonyms: LFA-2; LFA-3 receptor; SRBC; Rosette receptor; T-cell surface antigen CD2; Erythrocyte receptor; T-cell surface antigen T11/Leu-5
Amount: 100 μg
Application Codes Clone: IF; FC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody is directed against the CD2 antigen on human thymocytes and peripheral T lymphocytes. It also cross reacts with primate CD2. CD2 is a glycoprotein belonging to the immunoglobulin superfamily. It acts as a specific marker for T lymphocytes, natural killer cells, thymic B cell subsets, and some antigen presenting cells. CD2 interacts with CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Application Notes: Immunofluorescence staining was used to identify the binding specificity of this antibody. It was found that this antibody binds 95% of infant thymocytes, staining both cortical and medullary cells, 65-80% of blood lymphocytes and selectively stain the T cell-dependent paracortical areas of tonsil. This antibody was also reported to block sheep E rosette formation (PMID: 6977453). This antibody was used in a flow-cytometric immunofluorescence procedure for enumerating E-rosette lymphocytes from whole blood (PMID: 6751609). This antibody was used in a study of lymph node tissues from Macaca mulatta, M. speciosa, and M. fascicularis using immunoperoxidase staining (PMID: 3233792).

Product Class:	Purified
Clone ID:	OKT11
Synonyms:	LFA-2; LFA-3 receptor; SRBC; Rosette receptor; T-cell surface antigen CD2; Erythrocyte receptor; T-cell surface antigen T11/Leu-5
Amount:	100 μg
Application Codes Clone:	IF; FC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody is directed against the CD2 antigen on human thymocytes and peripheral T lymphocytes. It also cross reacts with primate CD2. CD2 is a glycoprotein belonging to the immunoglobulin superfamily. It acts as a specific marker for T lymphocytes, natural killer cells, thymic B cell subsets, and some antigen presenting cells. CD2 interacts with CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Application Notes:	Immunofluorescence staining was used to identify the binding specificity of this antibody. It was found that this antibody binds 95% of infant thymocytes, staining both cortical and medullary cells, 65-80% of blood lymphocytes and selectively stain the T cell-dependent paracortical areas of tonsil. This antibody was also reported to block sheep E rosette formation (PMID: 6977453). This antibody was used in a flow-cytometric immunofluorescence procedure for enumerating E-rosette lymphocytes from whole blood (PMID: 6751609). This antibody was used in a study of lymph node tissues from Macaca mulatta, M. speciosa, and M. fascicularis using immunoperoxidase staining (PMID: 3233792).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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