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Mfg Part Number

Ab05100-23.0

Vector Labs Ab05100-23.0 Anti-uPAR [3C6 ], Rabbit IgG, lambda (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was isolated from a fully human naïve Fab phage display library constructed from the conversion of peripheral blood lymphocyte RNA into cDNA. The particular antibody clone was isolated by panning the library against human soluble uPAR that was immobilized to a Nunc Maxisorp™.

$570.70

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Description

Product Class: Purified
Clone ID: 3C6
Synonyms: CD87; U-PAR; MO3; PLAUR; Urokinase plasminogen activator surface receptor; Monocyte activation antigen Mo3
Amount: 100 μg
Application Codes Clone: inhibit; functional assay; FC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds human urokinase plasminogen activator receptor (uPAR). It does not cross react with mouse or cynomolgus monkey uPAR. Human uPAR plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. Upregulation of uPAR expression at the cell surface, and plasminogen activation, has been linked to a number of conditions including inflammation, wound repair, arthritis, atherosclerosis angiogenesis, tumor invasion and metastasis.
Application Notes: The binding affinity of the IgG antibody towards human uPAR was reported to be Kd= 230 pM (PMID: 23400595).This antibody binds cell surface uPAR and abrogates uPAR association with α5β1 and α3β1 integrin. In a cell adhesion assay this antibody was found to facilitate a decrease in fibronectin- or vitronectin-dependent cell adhesion.

Product Class:	Purified
Clone ID:	3C6
Synonyms:	CD87; U-PAR; MO3; PLAUR; Urokinase plasminogen activator surface receptor; Monocyte activation antigen Mo3
Amount:	100 μg
Application Codes Clone:	inhibit; functional assay; FC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds human urokinase plasminogen activator receptor (uPAR). It does not cross react with mouse or cynomolgus monkey uPAR. Human uPAR plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. Upregulation of uPAR expression at the cell surface, and plasminogen activation, has been linked to a number of conditions including inflammation, wound repair, arthritis, atherosclerosis angiogenesis, tumor invasion and metastasis.
Application Notes:	The binding affinity of the IgG antibody towards human uPAR was reported to be Kd= 230 pM (PMID: 23400595).This antibody binds cell surface uPAR and abrogates uPAR association with α5β1 and α3β1 integrin. In a cell adhesion assay this antibody was found to facilitate a decrease in fibronectin- or vitronectin-dependent cell adhesion.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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