Mfg Part Number
Ab05137-1.1
Vector Labs Ab05137-1.1 Anti-Factor VIII [RHD5], Mouse IgG1, lambda (100 μg)
Quick Overview
This antibody was raised from B lymphocutes from a patient who developed an autoimmune response to Factor VIII.
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| Product Class: | Purified |
|---|---|
| Clone ID: | RHD5 |
| Synonyms: | AHF; Coagulation factor VIII; Antihemophilic factor; Procoagulant component |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; functional assay; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the C1 domain of Factor VIII. |
| Application Notes: | This antibody was used for an ELISA on Factor VIII, it showed binding. This antibody showed partial inhibition of Factor VIII in a Bethesda assay, with 97% inhibition at 100 ug/mL. This antibody was tested on human and mice plasma for its ability to inhibit Factor VIII, it showed it was able to inhibit 80% of Factor VIII in human plasma but showed no inhibition for mouse Factor VIII. It did partially inhibit Factor VIII when recombinant human Factor VIII was added to plasma of Factor VIII deficient mice. This antibody was tested in vivo on Factor VIII deficient mice, a part of these mice were injected with both Factor VIII and this antibody, and it showed that Factor VIII was only partially inhibited (US8784816B2). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |