Mfg Part Number
Ab05139-6.1
Vector Labs Ab05139-6.1 Anti-HMGB1 [6E6], Rat IgG1, kappa (100 μg)
Quick Overview
This antibody was raised by immunizing a BALB/c mouse with CBP-rat HMGB1 (CBP fused to amino acids 1-215 of rat HMGB1).
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 6E6 |
| Synonyms: | Hmg-1; Hmg1; Amphoterin; Heparin-binding protein p30; High mobility group protein 1; High mobility group protein B1 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; in vitro; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for rat HMGB1 |
| Application Notes: | The original antibody was used for an ELISA on rat HMGB1. The ability of this antibody to inhibit TNF release was determined, it showed it was able to inhibit TNF release. This antibody was used in a sepsis mouse model (caused by perforating a surgically-created cecal diverticulum), it was shown that administering this antibody to these mice increased survival with 10 ug being the optimal dose (US8846047B2). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |