Vector Labs Ab05163-10.0 Anti-IGF [KM1468], Human IgG1, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: KM1468
Synonyms: MGF; IGF-I; Somatomedin-C; Somatomedin-A; insulin-like growth factor; Insulin-like growth factor 1; Insulin-like growth factor 2; Insulin-like growth factor II; Mechano growth factor; T3M-11-derived growth factor
Amount: 100 μg
Application Codes Clone: ELISA; SPR; in vitro; in vivo
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: The antibody was specific for IGF.
Application Notes: The specificity of the original format of the antibody was confirmed by competitive ELISA. hIGF-I and hIGF-II were inhibited by the original format of the antibody. The binding affinity of the original format of the antibody to hIGF-I and hIGF-II was measured by surface plasmon resonance (Ka = 7.86×10^9 M^−1 and 8.63×10^9 M^−1 for hIGF-I and hIGF-II respectively). The original format of the antibody strongly inhibited the human breast cancer cell line MCF7 growth by hIGF-I and hIGF-II. The original format of the antibody inhibited the growth of a human colon cancer cell strain HT-29 and the growth of a human osteosarcoma cell strain MG63 by hIGF-I and hIGF-II. The original format of the antibody could inhibit the autocrine cell growth by the hIGF-I produced by the cell itself. The original format of the antibody could inhibit the anchorage independent growth of hIGF-I expressing cells. The original format of the antibody inhibited the growth of tumors in vivo due to the inhibition of hIGF-I (US7438911B2).

Product Class:	Purified
Clone ID:	KM1468
Synonyms:	MGF; IGF-I; Somatomedin-C; Somatomedin-A; insulin-like growth factor; Insulin-like growth factor 1; Insulin-like growth factor 2; Insulin-like growth factor II; Mechano growth factor; T3M-11-derived growth factor
Amount:	100 μg
Application Codes Clone:	ELISA; SPR; in vitro; in vivo
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	The antibody was specific for IGF.
Application Notes:	The specificity of the original format of the antibody was confirmed by competitive ELISA. hIGF-I and hIGF-II were inhibited by the original format of the antibody. The binding affinity of the original format of the antibody to hIGF-I and hIGF-II was measured by surface plasmon resonance (Ka = 7.86×10^9 M^−1 and 8.63×10^9 M^−1 for hIGF-I and hIGF-II respectively). The original format of the antibody strongly inhibited the human breast cancer cell line MCF7 growth by hIGF-I and hIGF-II. The original format of the antibody inhibited the growth of a human colon cancer cell strain HT-29 and the growth of a human osteosarcoma cell strain MG63 by hIGF-I and hIGF-II. The original format of the antibody could inhibit the autocrine cell growth by the hIGF-I produced by the cell itself. The original format of the antibody could inhibit the anchorage independent growth of hIGF-I expressing cells. The original format of the antibody inhibited the growth of tumors in vivo due to the inhibition of hIGF-I (US7438911B2).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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