Mfg Part Number
bAb0136
Vector Labs bAb0136 Anti-TRP-1, gp75 [TA99], Mouse IgG2a mCD3e KIH bispecific, Fc Silent™, kappa (50 μg)
Quick Overview
70-75 kDa pigmentation-associated glycoprotein in human melanoma cell lines.
$531.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | TA99 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Melanoma antigen gp75; 5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; Catalase B; Glycoprotein 75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1 |
| Amount: | 50 μg |
| Application Codes Clone: | ELISA; FC; IF; IHC-Fr; IP; WB |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against TRP-1 (Fab) and one arm directed against mouse CD3e (scFv). |
| Specificity Statement: | Binds Tyrosinase-related protein-1 (TRP-1), a 70-75k enzyme located in melanocytes, which are specialized cells that produce a pigment called melanin, helping to stabilize tyrosinase, which is the enzyme responsible for the first step in melanin production and determine the shape of melanosomes, which are the structures in melanocytes where melanin is produced. |
| Application Notes: | This antibody binds to human and murine TRP-1 and had been under evaluation for the treatment of tumours. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |